Browsing by Author "Brown, Timothy D."
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Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
Alcantara, Rosemarie B.; Read, Richard D. A.; Valderas, Michelle Wright; Brown, Timothy D.; Roop, R. Martin II (East Carolina University, 2004-08)Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ... -
The Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice
Anderson, Eric; Paulley, James T.; Gaines, Jennifer M.; Valderas, Michelle W.; Martin, Daniel W.; Menscher, Evan A.; Brown, Timothy D.; Burns, Colin Sanderson; Roop II, R. Martin (East Carolina University, 2009-08)The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the manganese transporter MntH. Phenotypic analysis of an isogenic mntH mutant indicates that MntH is the sole high-affinity ...