Browsing by Author "Buttke, Thomas M."
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Absence of unsaturated fatty acid synthesis in murine T lymphocytes.
Buttke, Thomas M.; Van Cleave, Steven; Steelman, Linda; McCubrey, James A. (East Carolina University, 1989-08)Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to ... -
Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.
Sandstrom, Paul A.; Buttke, Thomas M. (East Carolina University, 1993-05-15)CCRF-CEM is a human T-cell line originally isolated from a child with acute lymphoblastic leukemia. At cell densities > 2 x 10 cells per ml, CEM cells grow in serum-free medium, but at lower cell densities the cultures ... -
Molecular basis for the immunosuppressive action of stearic acid on T cells.
Tebbey, P. W.; Buttke, Thomas M. (East Carolina University, 1990-07)Studies were performed to determine the mechanism by which stearic acid (18: 0) selectively inhibits T-dependent immune responses in vitro. Incubation of mitogen-activated B and T cells with 18:0 resulted in dissimilar ... -
Regulation of oleic acid synthesis in lymphoid cells
Lowe, Martha R.