Browsing by Author "Cusimano, Antonella"
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Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
Cusimano, Antonella; Puleio, Roberto; D'Alessandro, Natale; Loria, Guido R.; McCubrey, James A.; Montalto, Giuseppe; Cervello, Melchiorre (2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
Cusimano, Antonella; Puleio, Roberto; D'Alessandro, Natale; Loria, Guido R.; McCubrey, James A.; Montalto, Giuseppe; Cervello, Melchiorre (2014)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited ... -
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
Cervello, Melchiorre; Bachvarov, Dimcho; Lampiasi, Nadia; Cusimano, Antonella; Azzolina, Antonina; McCubrey, James A.; Montalto, Giuseppe (2013-06-12)Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although ... -
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
Cervello, Melchiorre; Bachvarov, Dimcho; Lampiasi, Nadia; Cusimano, Antonella; Azzolina, Antonina; McCubrey, James A.; Montalto, Giuseppe (2013)Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although ... -
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
Cervello, Melchiorre; McCubrey, James A.; Cusimano, Antonella; Lampiasi, Nadia; Azzolina, Antonina; Montalto, Giuseppe (2012-03)Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ... -
Targeted therapy for hepatocellular carcinoma: Novel agents on the horizon
Cervello, Melchiorre; McCubrey, James A.; Cusimano, Antonella; Lampiasi, Nadia; Azzolina, Antonina; Montalto, Giuseppe (2012-03-31)Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ...