Browsing by Author "Dasari, Anvesh K. R."
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Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis
Dasari, Anvesh K. R. (East Carolina University, 2018-07-24)Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ... -
Tau Induces Formation of α-synuclein Filaments with Distinct Molecular Conformations
Dasari, Anvesh K. R.; Lim, Kwang Hun; Hojjatian, Alimohammad; Sengupta, Urmi; Taylor, Dianne; Daneshparvar, Nadia; Yeganeh, Fatemeh Abbasi; Dillard, Lucas; Michael, Brian; Griffin, Robert G.; Borgnia, Mario; Kayed, Rakez; Taylor, Kenneth A. (2021) -
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
Dasari, Anvesh K. R.; Hughes, Robert M.; Wi, Sungsool; Hung, Ivan; Gan, Zhehong; Kelly, Jeffrey W.; Lim, Kwang Hun (2019-01-10)Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identifed and characterized cytotoxic oligomeric ...