Browsing by Author "Dong, Lixue"
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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, Calvin R.; Dong, Lixue; Yang, Li V. (2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, Calvin R.; Dong, Lixue; Yang, Li V (2013-12-05)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
Dong, Lixue; Krewson, Elizabeth A.; Yang, Li V. (2017-01-27)Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ... -
Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
Dong, Lixue; Li, Zhigang; Leffler, Nancy R.; Asch, Adam S.; Chi, Jen-Tsan; Yang, Li V. (2013)Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood ... -
Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8
Li, Zhigang; Dong, Lixue; Dean, Eric; Yang, Li V. (2013-10)Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein ... -
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
Chen, Aishe; Dong, Lixue; Leffler, Nancy R.; Asch, Adam S.; Witte, Owen N.; Yang, Li V. (2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Justus, Calvin R.; Sanderlin, Edward J.; Dong, Lixue; Sun, Tianai; Chi, Jen-Tsan; Lertpiriyapong, Kvin; Yang, Li V. (2017-12)Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ... -
Evaluating Multipulse Integration as a Neural-Health Correlate in Human Cochlear-Implant Users: Relationship to Psychometric Functions for Detection
Zhou, Ning; Dong, Lixue (2017-01)In electrical hearing, multipulse integration (MPI) describes the rate at which detection threshold decreases with increasing stimulation rate in a fixed-duration pulse train. In human subjects, MPI has been shown to be ... -
Perception of Speaker Sincerity in Complex Social Interactions by Cochlear Implant Users
Rothermich, Kathrin; Dixon, Susannah; Weiner, Marti; Capps, Madison; Dong, Lixue; Zhou, Ning; Paquette, Se´bastien (2022-06-08) -
Sensitivity to Pulse Phase Duration as a Marker of Neural Health Across Cochlear Implant Recipients and Electrodes
Zhou, Ning; Dong, Lixue; Zhu, Zhen; Galvin, John, III (2021-02-08)