Browsing by Author "Fisher-Wellman, Kelsey H."
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Alterations in Sphingolipid Composition and Mitochondrial Bioenergetics Represent Synergistic Therapeutic Vulnerabilities Linked to Multidrug Resistance in Leukemia
Fisher-Wellman, Kelsey H.; Hagen, James T.; Nelson, Margaret A. M.; McLaughlin, Kelsey L.; Coalson, Hannah S.; Kassai, Miki; Kao, Li-Pin; Cabot, Myles C. (2022-01) -
Bioenergetic Consequences of Compromised Mitochondrial DNA Repair in the Mouse Heart
McClung, Joseph M.; McLaughlin, Kelsey L.; Fisher-Wellman, Kelsey H. (2018-10-01) -
Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration
McLaughlin, Kelsey L.; Nelson, Margaret A.M.; Coalson, Hannah S.; Hagen, James T.; Montgomery, McLane M.; Fisher-Wellman, Kelsey H.; Wooten, Ashley R.; Zeczycki, Tonya N.; Vohra, Nasreen A. (2022-06-08) -
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
Fisher-Wellman, Kelsey H. (East Carolina University, 2013)Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ... -
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt
Su, Zhiduan; Burchfield, James G.; Yang, Pengyi; Humphrey, Sean J.; Yang, Guang; Francis, Deanne; Yasmin, Sabina; Shin, Sung-Young; Norris, Dougall M.; Kearney, Alison L.; Astore, Miro A.; Scavuzzo, Jonathan; Fisher-Wellman, Kelsey H.; Wang, Qiao-Ping; Parker, Benjamin L.; Neely, G. Gregory; Vafaee, Fatemeh; Chiu, Joyce; Yeo, Reichelle; Hogg, Philip J.; Fazakerley, Daniel J.; Nguyen, Lan K.; Kuyucak, Serdar; James, David E. (2019-12-02)Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude and extent of crosstalk between oxidation and other post-translational modifications remains unclear. Here, we delineate global ... -
Human Studies of Mitochondrial Biology Demonstrate an Overall Lack of Binary Sex Differences: A Multivariate Meta-Analysis
Fisher-Wellman, Kelsey H.; Neufer, P. Darrell; Junker, Alex (2022) -
Interventional- and Amputation-Stage Muscle Proteomes in the Chronically Threatened Ischemic Limb
Green, Thomas D.; Karnekar, Reema; Fisher-Wellman, Kelsey H.; Yamaguchi, Dean J.; McClung, Joseph M. (2022) -
Mitochondrial alterations accompany forced differentiation in acute myeloid leukemia.
Coalson, Hannah S. (East Carolina University, 2022-05-09)Leukemia is characterized by blocked hematopoietic differentiation. Blocked differentiation results in the uncontrolled proliferation of immature, malignant myeloblasts. To counteract myeloblast proliferation, forced ... -
Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes
Fisher-Wellman, Kelsey H.; Davidson, Michael T.; Narowski, Tara M.; Lin, Chien-Te; Koves, Timothy R.; Muoio, Deborah M. (2018-09-25)Chronic metabolic diseases have been linked to molecular signatures of mitochondrial dysfunction. Nonetheless, molecular remodeling of the transcriptome, proteome, and/or metabolome does not necessarily translate to ... -
Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
Fisher-Wellman, Kelsey H.; Weber, Todd M.; Cathey, Brook L.; Brophy, Patricia; Gilliam, Laura A. A.; Kane, Constance L.; Maples, Jill M.; Gavin, Timothy Patrick; Houmard, Joseph A.; Neufer, P. Darrell (2014-01)Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to ... -
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
Fisher-Wellman, Kelsey H.; Mattox, Taylor A.; Thayne, Kathleen; Katunga, Lalage Adalaide; La Favor, Justin D.; Neufer, P. Darrell; Hickner, Robert C.; Wingard, Christopher J.; Anderson, Ethan (2013)Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ... -
Octanoate is Differentially Metabolized in Liver and Muscle and Fails to Rescue Cardiomyopathy in CPT2 Deficiency
Pereyra, Andrea S.; Ellis, Jessica M.; Fisher-Wellman, Kelsey H.; Harris, Kate L.; Soepriatna, Arvin H.; Waterbury, Quin A.; Bharathi, Sivakama S.; Zhang, Yuxun; Goergen, Craig J.; Goetzman, Eric S. (2021) -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
McClung, Joseph M.; Ryan, Terence E.; Spangenburg, Espen E.; Schmidt, Cameron A.; Tarpey, Michael D.; Amorese, Adam J.; Yamaguchi, Dean J.; Goldberg, Emma J.; Iñigo, Melissa M.R.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Neufer, P. Darrell; Fisher-Wellman, Kelsey H.; Spangenburg, Espen E. (2020-09-17) -
Subcellular Proteomics Combined with Bioenergetic Phenotyping Reveals Protein Biomarkers of Respiratory Insufficiency in the Setting of Proofreading-Deficient Mitochondrial Polymerase
McClung, Joseph M.; McLaughlin, Kelsey L.; Kew, Kimberly A.; Fisher-Wellman, Kelsey H. (2020-02-27) -
Tissue-specific characterization of mitochondrial branchedchain keto acid oxidation using a multiplexed assay platform
Nguyen, Tiffany (East Carolina University, 2021-04-23)Alterations to branched-chain keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although global shifts in BCKA metabolism-evident by gene transcription, ...