Browsing by Author "Ghosh, Debjani"
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IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis
Wang, Duncheng; Ghosh, Debjani; Islam, Touhidul; Moorman, Cody; Thomason, Ashton; Wilkinson, Daniel; Mannie, Mark (2016-10-15)This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three components, IFN-β, NAg, and Alum, for ... -
Partial cD25 antagonism enables Dominance of antigen-inducible cD25high FOXP3+ regulatory T cells as a Basis for a regulatory T cell- Based adoptive immunotherapy
Wilkinson, Daniel S.; Ghosh, Debjani; Nickle, Rebecca A.; Moorman, Cody D.; Mannie, Mark D. (2017-12-14)FOXP3+ regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy ... -
Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling
Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C. (2013)Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ... -
Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling
Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C. (2013-08-27)Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ...