Browsing by Author "Hughes, Robert M"
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Design and Application of an Immobilized Protein Kinase
Schulz, Anna (East Carolina University, 2023-04-26)Protein Kinase A (PKA) is a biologically important enzyme for cell regulation, often referred to as the “central kinase”. An immobilized PKA that retains native substrate specificity and activity would be a useful tool for ... -
Investigation of Neurodegenerative Disease-related Cofilin-Actin Rod Dynamics Using a Novel Optogenetic Approach
Roberts, Davis Keith (East Carolina University, 2023-12-15)The presence of actin-cofilin rods in neurons is a common feature of a multitude of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntingtin’s disease (Bamburg, et al 2010). These ... -
Red Blood Cell Preservation Under Austere Conditions
Angermeier, Tori Marena (East Carolina University, 2023-01-05)In the United States, the maximum approved preservation time for red blood cells under hypothermic storage conditions is 42 days when treated with an appropriate additive solution, namely AS-1. In this investigation, we ...