Browsing by Author "Hvastkovs, Eli G."
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ANALYSIS OF OXYGENATED POLYCYCLIC AROMATIC HYDROCARBONS AND THEIR PARENT MOLECULES IN BIOCHAR AND ITS LEACHATES
Phillips, Stephanie Caroline Webb (East Carolina University, 2017-12-13)Due to the increasing use of biochar as a soil amendment, the amount and composition of contaminants in biochar should be analyzed. Two of those suites of compounds in biochar are polycyclic aromatic hydrocarbons (PAHs) ... -
Detection of Environmental DNA Damage Using Electrochemical Sensors and Mass Spectrometry
Schaaf, Nicholas Joseph (East Carolina University, 2018-05-04)Nickel exposure has been linked to a variety of health complications including instances of tumors and cancer in living organisms. Exposure to nickel can occur due to pollution from mining or industrial applications. ... -
Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
Vinogradov, Sergey M. (East Carolina University, 2015)Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ... -
ELECTROCHEMICAL DETECTION OF BENZO[A]PYRENE METABOLITE DNA DAMAGE : IMPLICATIONS OF NUCLEOBASE SEQUENCE AND ADDUCT STEREOCHEMISTRY
Satterwhite, Jennifer Elizabeth (East Carolina University, 2011)Xenobiotics are chemical compounds introduced to living organisms that originate outside the body. A well-studied xenobiotic is benzo[a]pyrene (BP), a polyaromatic hydrocarbon (PAH) primarily introduced into the body via ... -
Electrochemical Detection of Benzo[a]Pyrene-Induced DNA Damage at TP53 Oligomers : Impact of 5'-Methyl Cytosine and Bioactivation on the Genotoxicity Process
Trumbo, Caitlin M. (East Carolina University, 2014)DNA houses the blueprint that dictates how an organism will develop. However, DNA features numerous reactive sites that can be attacked by chemicals and radiation, resulting in DNA damage and possibly mutations. Chemical ... -
Identification of Damaged DNA Adducts from Exposure to Benzo[a]pyrene in the TP53 Gene
Taylor, Lea (2015)Benzo[a]pyrene is a carcinogen associated with tobacco smoke that can damage DNA after it is metabolized into highly reactive forms. Identifying the resulting DNA adducts can give greater insight into the mutations that ...