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  • Acid ceramidase is upregulated in AML and represents a novel therapeutic target 

    Tan, Su-Fern; Liu, Xin; Fox, Todd E.; Barth, Brian M.; Sharma, Arati; Turner, Stephen D.; Awwad, Andy; Dewey, Alden; Doi, Kenichiro; Spitzer, Barbara; Shah, Mithun Vinod; Morad, Samy A.F.; Desai, Dhimant; Amin, Shantu; Zhu, Junjia; Liao, Jason; Yun, Jong; Kester, Mark; Claxton, David F.; Wang, Hong-Gang; Cabot, Myles C.; Schuchman, Edward H.; Levine, Ross L.; Feith, David J.; Loughran, Thomas P. Jr. (2016-12-13)
    There is an urgent unmet need for new therapeutics in acute myeloid leukemia (AML) as standard therapy has not changed in the past three decades and outcome remains poor for most patients. Sphingolipid dysregulation through ...