Browsing by Author "Keswani, Amit N."

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  • Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries 

    Peyton, Kelly J.; Ensenat, Diana; Azam, Mohammad A.; Keswani, Amit N.; Kannan, Sankaranarayanan; Liu, Xiao-Ming; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-04)
    Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ...

  • The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects 

    Keswani, Amit N.; Peyton, Kelly J.; Durante, William; Schafer, Andrew I.; Tulis, David A. (East Carolina University, 2009-06)
    Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ...