Browsing by Author "Roper, Rachel L."
-
Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
Brodie, Ryan; Smith, Alex J.; Roper, Rachel L.; Tcherepanov, Vasily; Upton, Chris (East Carolina University, 2004-07-14)Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than gene content because two strains of an ... -
Characterization of the Vaccinia Virus A35R Protein and Its Role in Virulence
Roper, Rachel L. (East Carolina University, 2006-01)The vaccinia virus A35R gene is highly conserved among poxviruses and encodes a previously uncharacterized hydrophobic acidic protein. Western blotting with anti-A35R peptide antibodies indicated that the protein is ... -
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
Roper, Rachel L. (2006-03-01)Two different severe acute respiratory syndrome (SARS) vaccine strategies were evaluated for theirability to protect against live SARS coronavirus (CoV) challenge in a murine model of infection.A whole killed (inactivated ... -
The effects of diets enriched in omega-3 polyunsaturated fatty acids on systemic vaccinia virus infection
Jones, Gwendolyn J. B.; Roper, Rachel L. (2017-11-22)Omega-3 polyunsaturated fatty acids (PUFA, n-3 fatty acids), the key components of fish and flaxseed oils, are increasingly consumed by the public because of their potential health benefits and are available by prescription ... -
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
Freistaedter, Andrew G. (East Carolina University, 2012)Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ... -
Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
Zervos, Emmanuel; Agle, Steven C.; Freistaedter, Andrew G.; Jones, Gwendolyn J. B.; Roper, Rachel L. (2016-03)Background Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothelin ... -
The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response
Rehm, Kristina Elizabeth (East Carolina University, 2010)Poxviruses are large double-stranded DNA viruses with a broad host range and worldwide distribution. The most infamous poxvirus is Variola virus, the causative agent of smallpox, which caused over 500 million deaths in ... -
SARS-CoV-2 Detection in Air Samples from Inside Heating, Ventilation, and Air Conditioning (HVAC) Systems- COVID Surveillance in Student Dorms
Sousan, Sinan; Fan, Ming; Outlaw, Kathryn; Williams, Sydney; Roper, Rachel L. (2022) -
Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses
Ahsendorf, Henrike P.; Gan, Li L.; Eltom, Kamal H.; Wahed, Ahmed Abd El; Hotop, Sven-Kevin; Roper, Rachel L.; Beutling, Ulrike; Broenstrup, Mark; Stahl-Hennig, Christiane; Hoelzle, Ludwig E.; Czerny, Claus-Peter (2019-05-29)The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus Orthopoxvirus (OPXV), are targets of viral neutralization by host antibodies. We have mapped six binding ...