Browsing by Author "Tatum, Rodney"
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Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
Fan, Junming; Tatum, Rodney; Hoggard, John; Chen, Yan-Hua (2019-07-30)Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ... -
Necrotizing enterocolitis leads to disruption of tight junctions and increase in gut permeability in a mouse model
Ravisankar, Srikanth; Tatum, Rodney; Garg, Parvesh M; Herco, Maja; Shekhawat, Prem S.; Chen, Yan-Hua (2018-11-27)Background: Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, ... -
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
Kim, Jin-Sook; Bareiss, Sonja; Kim, Kyung Keun; Tatum, Rodney; Han, Jeong-Ran; Jin, Yun Hye; Kim, Hangun; Lu, Qun; Kim, Kwonseop (East Carolina University, 2006-12-29)Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that ...