Browsing by Author "Walker, Lia R."
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DISINTEGRIN-LIKE DOMAIN IN KSHV ENCODED gB IS A NECESSITY TO PROMOTE VIRUS LATENCY
Walker, Lia R. (East Carolina University, 2011)KSHV glycoprotein B (gB) is a lytic structural protein expressed on the envelope of mature virions and on the membrane of cells supporting lytic infection. Previous studies have identified that in addition to the role of ... -
FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION
Walker, Lia R. (East Carolina University, 2015-12-10)KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma ... -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
Hussein, Hosni Ahmed Mohamed; Walker, Lia R.; Akula, Shaw M. (2016-02)Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, ... -
Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1
Dyson, Ossie F.; Walker, Lia R.; Whitehouse, Adrian; Cook, Paul P.; Akula, Shaw M. (2012)Article Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Media ... -
Resveratrol inhibits KSHV reactivation by lowering the levels of cellular Egr-1
Dyson, Ossie F.; Walker, Lia R.; Whitehouse, Adrian; Cook, Paul P.; Akula, Shaw M. (2012-03-12)In the field of herpesvirus research, the exact molecular mechanism by which such viruses reactivate from latency remains elusive. Kaposi's sarcoma-associated herpesvirus (KSHV) primarily exists in a latent state, while ... -
Subcellular fractionation method to study endosomal trafficking of Kaposi’s sarcoma-associated herpesvirus
Walker, Lia R.; Hussein, Hosni Ahmed Mohamed; Akula, Shaw M. (2016-01)Background Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles ... -
Subcellular fractionation method to study endosomal trafficking of Kaposis sarcoma-associated herpesvirus
Walker, Lia R.; Akula, Shaw M.; Hussein, Hosni A. M. (2016)Background: Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via ... -
Subcellular fractionation method to study endosomal trafficking of Kaposi’s sarcoma-associated herpesvirus
Walker, Lia R.; Hussein, Hosni Ahmed Mohamed; Akula, Shaw M. (2016-01-15)Background: Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles ...