Browsing by Author "Xie, Jialei"
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Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
Xie, Jialei; Zhi, Hui; Garrigues, Ryan J.; Keightley, Andrew; Garcia, Brandon L.; Skare, Jon T. (2019-03-21)The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...