Browsing by Author "Zheng, Donghai"
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The Association Between Lactate and Muscle Aerobic Substrate Oxidation: Is Lactate an Early Marker for Metabolic Disease in Healthy Subjects?
Broskey, Nicholas T.; Tanner, Charles J.; Zheng, Donghai; Cortright, Ronald N.; Yang, Zhen W.; Khang, Nkaujyi; Houmard, Joseph A.; Pories, Walter J.; Jones, Terry E.; Yang, Josh; Dohm, G. Lynis (2021) -
Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study
Chaves, Alec B.; Zheng, Donghai; Johnson, Jonathan A.; Biagioni, Ericka M.; Krassovskaia, Polina; Broskey, Nicholas T.; May, Linda E.; Houmard, Joseph A. (2022-08) -
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis (East Carolina University, 2008-12)Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ... -
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ... -
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle
Huang, Tai-Yu; Zheng, Donghai; Hickner, Robert C.; Brault, Jeffrey J.; Cortright, Ronald N. (2020-04-21)Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment ... -
Placental Mitochondria Response to Different Modes of Exercise During Pregnancy
Fountain, Sarah Rae (East Carolina University, 2022-08-21)Previous research shows exercise provides health benefits, and this is true in the context of pregnancy. However, little research has been done to examine placenta adaptations to exercise that mediate maternal and fetal ... -
Regulation of GLUT4 expression in denervated skeletal muscle
Jensen, Ellis B.; Zheng, Donghai; Russell, Robert A.; Bassel-Duby, Rhonda; Williams, R. Sanders; Olsen, Ann Louise; Dohm, G. Lynis (East Carolina University, 2009-03)Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known about the signaling events that cause this decrease. Experiments were designed to test the ...