Browsing by Author "Zhu, Yong"
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Adamts9 is critical for the development of primary ovarian follicles
Carver, Jonathan J (East Carolina University, 2022-07-19)Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. ... -
Adamts9 is critical for the development of primary ovarian follicles
Carver, Jonathan Jacob (East Carolina University, 2022-07-19)Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. ... -
Adamts9 is necessary for ovarian development in zebrafish
Roach, Zachary Adam (East Carolina University, 2020-05-04)Expression of adamts9 (A disintegrin and metalloprotease with thrombospondin type-1 motif, member 9) increases dramatically in the somatic cells surrounding oocytes during ovulation in vertebrates from zebrafish to human. ... -
ADAMTS9 IS NECESSARY FOR THE SEXUAL DEVELOPMENT OF FEMALE ZEBRAFISH
Carter, Nichole J. (East Carolina University, 2018-12-10)The ovary is a unique organ as it must cyclically alter its structure to accommodate the growth, development, and release of oocytes. The processes of oogenesis and ovulation requires structural modifications made to the ... -
Androgen and progesterone receptor knockouts in Danio rerio affect aggression and social dominance (part 1)
Chilton, Matthew W (East Carolina University, 2018-12-07)It is well known that competition for the basic resources of food, shelter, and mates will always exist in nature. The most prevalent method of competing for such resources is aggression and social dominance. There is ... -
ANDROGEN AND PROGESTERONE RECEPTORS KNOCKOUTS IN ZEBRAFISH AFFECT AGGRESSION AND SOCIAL DOMINANCE
Brown, Julia N (East Carolina University, 2019-05-03)ABSTRACT - There is circumstantial evidence that steroids, such as androgens and progesterone, play roles in aggression and social behaviors in vertebrates. However, the genetic basis for these behaviors needs to be further ... -
Characterization and Expression of the Nuclear Progestin Receptor in Zebrafish Gonads and Brain
Hanna, Richard N.; Daly, Sean C. J.; Pang, Yeifei; Anglade, Isabelle; Kah, Olivier; Thomas, Peter; Zhu, Yong (2010-01-01)The zebrafish nuclear progestin receptor (nPR; official symbol PGR) was identified and characterized to better understand its role in regulating reproduction in this well-established teleost model. A full-length cDNA was ... -
Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio)
Wu, Xinjun (East Carolina University, 2020-06-22)It is well known that progestins initiate important reproductive processes such as oocyte maturation and ovulation in vertebrates. Progestins exert functions through binding to progestin receptors. At least three families ... -
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
Zhu, Yong; Rice, Charles D.; Pang, Yefei; Pace, Margaret; Thomas, Peter (East Carolina University, 2003-03-04)The structures of membrane receptors mediating rapid, nongenomic actions of steroids have not been identified. We describe the cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following ... -
DEHP Impairs Zebrafish Reproduction by Affecting Critical Factors in Oogenesis
Carnevali, Oliana; Tosti, Luca; Speciale, Claudia; Peng, Chun; Zhu, Yong; Maradonna, Francesca (East Carolina University, 2010-04-15)Public concerns on phthalates distributions in the environment have been increasing since they can cause liver cancer, structural abnormalities and reduce sperm counts in male reproductive system. However, few data are ... -
Delay in Primordial Germ Cell Migration in Adamts9 Knockout Zebrafsh
Carver, Jonathan J.; He, Yuanfa; Zhu, Yong (2021) -
FUNCTIONS OF G-PROTEIN COUPLED ESTROGEN RECEPTOR (GPER) IN FEMALE ZEBRAFISH REPRODUCTION
Williams, Marcus Jermaul Jawanza (East Carolina University, 2019-11-27)Abstract Steroid hormones such as estrogen depend on receptors like Estrogen Receptor alpha (ERα) and Estrogen Receptor (ERβ) to mediate their slow “genomic” functions, and G-Protein coupled Estrogen Receptor (GPER) to ... -
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
Zhu, Yong; Bond, Jason E.; Thomas, Peter (East Carolina University, 2003-03-04)Recently we discovered a previously uncharacterized gene with the characteristics of a membrane progestin receptor (mPR) in a fish model, spotted seatrout. Here, we report the identification, cloning, and characteristics ... -
LOCALIZATION AND CHANGES OF NUCLEAR PROGESTERONE RECEPTORS IN ZEBRAFISH OOCYTES AND ADJACENT FOLLICULAR CELLS
Daly, Sean C. J. (East Carolina University, 2010)The nuclear progesterone receptor (Pgr) is one of the major mediators for progestin signaling during oocyte ovulation in vertebrates. However, any roles Pgr may play in oocyte growth, and especially in the final oocyte ... -
NR5A family member ftz-f1 is necessary to promote oocyte development
McDonald, Samantha I (East Carolina University, 2019-07-15)Gamete production in mammals and insects is intimately tied to nutrition status. Conversion of nutritionally-dependent physiological signals to molecular mechanisms underlying control of oogenesis, however, remains largely ... -
Nuclear progesterone receptors are up-regulated by estrogens in neurons and radial glial progenitors in the brain of zebrafish
Diotel, Nicolas; Servili, Arianna; Gueguen, Marie-Madeleine; Mironov, Svetlana; Pellegrini, Elisabeth; Vaillant, Colette; Zhu, Yong; Kah, Olivier; Anglade, Isabelle (2011-11-30)In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone and/or its ... -
Nuclear Progesterone Receptors Are Up-Regulated by Estrogens in Neurons and Radial Glial Progenitors in the Brain of Zebrafish
Diotel, Nicolas; Servili, Arianna; Gueguen, Marie-Madeleine; Mironov, Svetlana; Pellegrini, Elisabeth; Vaillant, Colette; Zhu, Yong; Kah, Olivier; Anglade, Isabelle (2011)Abstract In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone ... -
Nuclear progestin receptor (Pgr) knockouts in zebrafish demonstrate role for Pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption
Zhu, Yong; Liu, Dongteng; Shaner, Zoe C.; Chen, Shixi; Hong, Wanshu; Stellwag, Edmund J. (2015)Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to become fertilizable eggs in ... -
Nuclear Progestin Receptor (Pgr) Knockouts in Zebrafish Demonstrate Role for Pgr in Ovulation but Not in Rapid Non-Genomic Steroid Mediated Meiosis Resumption
Zhu, Yong; Liu, Dongteng; Shaner, Zoe C.; Chen, Shixi; Hong, Wanshu; Stellwag, Edmund J. (2015-03)Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to become fertilizable eggs in basal ... -
Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
Wu, Xin-Jun; Thomas, Peter; Zhu, Yong (2018-09-24)Recent investigations suggest progestin receptor membrane component 1 (PGRMC1) associates with and transports a wide range of molecules such as heme, cytochromes P450, steroids with 21 carbons, membrane progestin receptor ...