Browsing by Subject "AMP deaminase"
Now showing items 1-4 of 4
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AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
(East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
Increased Degradation of Adenosine Monophosphate as a Regulator of Maximal Mitochondrial Respiration
(East Carolina University, 2019-07-02)Atrophied skeletal muscle have enhanced fatigability due at least in part to a reduction of mitochondria content. Mitochondrial biogenesis is regulated by the transcriptional coactivator PGC-1 alpha, which in turn is ... -
Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production
(East Carolina University, 2022-07-26)Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially ... -
Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production
(East Carolina University, 2022-07-26)Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially ...