Browsing by Subject "Amyloid"
Now showing items 1-4 of 4
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An Investigation of the Underlying Mechanism in Insulin Aggregation and Fibrillogenesis with Chelators
(East Carolina University, 2021-11-30)Amyloid is a proteastasis condition implicated in more than 50 different diseases. At the core of it is the protein structural modifications that leads to assembly of protein molecules into a unique cross-[beta] structure. ... -
Characterizing Interactions of Thioflavin-T with Native Proteins Especially Bovine Serum Albumin
(East Carolina University, 2017-05-03)Thioflavin T is a fluorescent probe used to monitor formation of cross [beta]-sheet rich amyloid fibrils. Involvement of the amyloid fibrils is implicated in more than 50 human diseases, such as Alzheimer's, Parkinson's ... -
Disintegration of Amyloid fibrils using chaperones, inorganic chemicals
(East Carolina University, 2021-11-29)Protein aggregation in the form of amyloid has been implicated in more than 50 human diseases. These diseases range from neuropathic, like Alzheimer's and Parkinson's, to common diseases like cataracts. The number of people ... -
Investigation of Curli-Specific Proteins CsgD and CsgA Reveals a Potential Target for Neurodegenerative Therapeutics and Provides Structural Insights into the Bacterial Amyloid CsgA
(East Carolina University, 2022-12-06)A growing body of evidence implicates curli-containing biofilms in the onset of neurodegenerative pathologies like Alzheimer's and Parkinson's diseases. Curli-containing biofilms are composed primarily of two bacterial ...