Browsing by Subject "Cell Transformation, Neoplastic"
Now showing items 1-5 of 5
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An examination of the functional role of TMEFF2 in prostate cancer and the translational regulatory mechanisms controlling its expression
(East Carolina University, 2012)Prostate cancer is the most commonly diagnosed cancer in American men and accounts for approximately 11% of cancer-related deaths. Although promising treatment strategies have been developed and are currently being tested ... -
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
(East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ... -
The Role of the Notch-3 Receptor in Stemness, EMT, and Tumorigenesis in Colorectal Cancer
(East Carolina University, 2016-05-05)As the second leading cause of cancer death worldwide, colorectal cancer (CRC) poses a significant threat to both men and women alike. Although a small percentage of CRC cases are inherited, the majority of cases arise ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ...