Browsing by Subject "Nicotine"
Now showing items 1-6 of 6
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Clinical Inquiries: What interventions can help patients stop using chewing tobacco?
(East Carolina University, 2005)This review article examines current literature to recommend interventions to help patients stop using chewing tobacco. -
Early Nicotine Exposure Altered Larval Neuromuscular Function and Adult Germline Apoptosis via MiRNA-Dependent Mechanisms
(East Carolina University, 2016-04-29)MicroRNAs fine tune the expression of target genes needed for homeostasis. Our pilot study showed that nicotine altered 17% miRNAs in C. elegans larvae. Here, we investigated the role of microRNAs in mediating nicotine-induced ... -
Effects of Nicotine on Caenorhabditis elegans survival, reproduction, and gene expressions : Development of an Invertebrate Animal Model for Drugs of Abuse
(East Carolina University, 2011)Although much is known about the addictive effects of nicotine, the molecular mechanisms of nicotine-induced effects remain largely unclear. Specifically, little is known about the effects of nicotine on gene expression, ... -
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
(2015-05)Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
(East Carolina University, 2013)Tobacco smoking is a worldwide epidemic that is responsible for diseases and death rates that surpass those attributed to a combination of other causes (e.g. cancer, HIV, accidents). A major mediator of tobacco-smoke related ...