Browsing by Subject "Drosophila"
Now showing items 1-11 of 11
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Determining the role of the steroid hormone ecdysone in critical stages of Drosophila melanogaster early oogenesis
(East Carolina University, 2019-11-27)Reproductive function in many organisms, including Drosophila melanogaster, is controlled by steroid hormones. The main steroid hormone in Drosophila is ecdysone, which is structurally and functionally similar to estrogen. ... -
Drosophila Ctf4 is essential for genome stability and normal cell cycle progression
(East Carolina University, 2010)Proper DNA replication and well-timed cell cycle progression are vital to the normal functioning of a cell. Precise coordination between these mechanisms' constituent proteins ensures their processivity while safeguarding ... -
Drosophila Oocytes as a Model for Understanding Meiosis: An Educational Primer to Accompany “Corolla Is a Novel Protein That Contributes to the Architecture of the Synaptonemal Complex of Drosophila”
(2015-01)Achieving a thorough understanding of the events and ramifications of meiosis is a common learning objective for undergraduate introductory biology, genetics, and cell biology courses. Meiosis is also one of the most ... -
Drosophila Psf2 Has a Role In Chromosome Condensation
(East Carolina University, 2012)The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, ... -
EXERCISE AND DIET PROGRAMS DROSOPHILA SIMULANS OFFSPRING METABOLIC PHENOTYPE
(East Carolina University, 2021-04-23)Obesity in pediatric patients has increased significantly in recent decades, along with susceptibility to Type 2 Diabetes (T2D), cardiovascular disease, cancer, and mortality. The relative contribution of genetic and ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the role of TER94 in Drosophila melanogaster germ cells
(East Carolina University, 2021-05-28)Mutations in Valosin-Containing Protein (VCP) can lead to onset of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease; however, the intracellular functions of VCP in cells remain unclear. To study the ... -
Mechanisms of germ cell development in Drosophila oogenesis.
(East Carolina University, 2018-07-17)Germ cell development requires interplay between factors that control cell fate and division. Early in their development, germ cells are an interconnected group of mitotically dividing cells. Key regulatory events then ... -
Sld5, A Subunit of the Heterotetrameric GINS Complex is Necessary for Normal Cell Cycle Progression and Genomic Stability
(East Carolina University, 2010)Sld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically, GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised ... -
THE ROLE OF HNRNPS ON THE ESTABLISHMENT AND MAINTENANCE OF GERMLINE STEM CELLS IN DROSOPHILA MELANOGASTER
(East Carolina University, 2018-05-03)An organism’s ability to grow and regulate tissue repair relies on the stimulation of stem cells in response to changes in physiological state, such as cell damage, sexual maturation and growth. Tissue-resident stem cells ... -
The Role of Pre-Replication Complex Proteins in Drosophila Ovarian Stem Cell Maintenance and Proliferation
(East Carolina University, 2017-05-05)Cancer stem cells (CSCs) may hold the key to advances in cancer research. Like adult tissue-specific stem cells, CSCs are able to self-renew and last a lifetime. These shared characteristics can thus be used to help learn ...