Browsing by Subject "Enzymes"
Now showing items 1-4 of 4
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AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
(East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
Biophysical Investigation into the Protein Dynamics Governing the Allosteric Regulation of Plant and Animal 15-Lipoxygenases
(East Carolina University, 2022-04-27)Lipoxygenases (LOXs) are a family of enzymes found in plants, animals, fungi, and bacteria that catalyze the per-oxidation of polyunsaturated fatty acids. In plants, LOXs are involved in growth, development, and defense ... -
DEVELOPMENT OF UNNATURAL SUBSTRATES AND TRYPTOPHAN AMINO ACIDS TO STUDY PROTON COUPLED ELECTRON TRANSFER IN ENZYMES
(East Carolina University, 2020-12-09)Proton-coupled electron transfer plays an important role in substrate oxidation by C-H bond cleavage and long-range pathways associated with bioenergetics. This thesis is focused on the synthesis of unnatural substrates ... -
Mechanistic Strategies of Two-component Flavin-dependent Monooxygenases Involved in Sulfur Acquisition
(East Carolina University, 2023-08-09)All organisms require sulfur for diverse metabolic and physiological processes. Unlike mammals, bacteria are often deprived of sulfur in their natural habitat. To meet their sulfur needs, bacteria express various proteins ...