Browsing by Subject "Insulin"
Now showing items 1-6 of 6
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An Investigation of the Underlying Mechanism in Insulin Aggregation and Fibrillogenesis with Chelators
(East Carolina University, 2021-11-30)Amyloid is a proteastasis condition implicated in more than 50 different diseases. At the core of it is the protein structural modifications that leads to assembly of protein molecules into a unique cross-[beta] structure. ... -
Disintegration of Amyloid fibrils using chaperones, inorganic chemicals
(East Carolina University, 2021-11-29)Protein aggregation in the form of amyloid has been implicated in more than 50 human diseases. These diseases range from neuropathic, like Alzheimer's and Parkinson's, to common diseases like cataracts. The number of people ... -
Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats
(East Carolina University, 2009)Gastric bypass surgery (RYGBP) for the treatment of obesity has proven to clinically reverse type 2 diabetes mellitus. RYGBP involves both gastric reduction and bypass of the proximal small intestine. Duodenal-Jejunal ... -
Effects of High-Insulin Exposure on Mitochondrial Content in Skeletal Muscle Myotubes from Lean & Severely Obese Individuals: A Time Course Analysis
(East Carolina University, 2016-08-01)Skeletal muscle is the site at which highly regulated energetic processes take place as a means of maintaining both tissue-specific and whole-body metabolism. With the development of severe obesity (BMI [greater-than] or ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
(East Carolina University, 2012)Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ...