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Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
(East Carolina University, 2012)
Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ...
Differential aging-related changes of D1, D2, and D3 dopamine receptor expression in the striatum
(2013-05-03)
Aging is associated with a decrease in motor function and a concomitant increase in muscle stiffness and tone. The striatum plays a critical role in the control of motor function, and it receives strong dopamine (DA) ...
miRDiabetes : A microRNA-Diabetes Association Database Constructed With Data Mining on Literature
(East Carolina University, 2014)
MicroRNAs (miRNAs) are a growing class of non-coding RNAs that regulate gene expression by translational repression. A role for miRNA in diabetes was first established in 2004 and research in miRNA-diabetes association has ...
Hypoxia and Serum Deprivation in Human Mesenchymal Stem Cells, and the Protective Role of Thymosin [Beta]-4
(East Carolina University, 2011)
Background: Current literature suggests nutrient deprivation and hypoxia affect human mesenchymal stem cell (hMSC) survival after cell transplantation. Wound-healing protein Thymosin [beta]-4 (T[beta]-4) has been shown ...