Browsing Dissertations and Theses by Author "Garcia, Brandon L"
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Targeting the initiating proteases of the complement system using structure-based small molecule drug discovery
Rohlik, Denise Lauren (East Carolina University, 2023-07-21)The complement system is an essential element of host development and immune homeostasis. This immunoregulatory enzyme cascade is driven by serine protease activation and plays critical roles in the recognition of danger ... -
TLR-4 agonism induces CD25+ MHCIIhigh dendritic cells in association with tolerogenic antigen recognition
Bastian, Alexander (East Carolina University, 2022-12-06)Autoimmune disease is a result of the breakdown in immunological self-tolerance leading to destruction of self-tissues mediated by the aberrant immune attack. In Multiple Sclerosis (MS), CD4+ T cells mediate destruction ...