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Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
(East Carolina University, 2017-07-25)
The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ...
Behavioral and genetic divergence among wild and domesticated populations of the zebra finch (Taeniopygia guttata)
(East Carolina University, 2017-07-18)
Zebra finches (Taeniopygia guttata) have been the subject of extensive neurological and behavioral research having served as the dominant model for vocal learning over half a century. Learned vocal communication, or vocal ...
Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles
(East Carolina University, 2017-07-17)
In radiation therapy for the treatment of cancer, there is demand for novel approaches that will improve tumor cell killing while protecting healthy tissue. One such approach that has shown considerable promise is the ...
The Relationships Between Physical Capacity And Biomechanical Plasticity With Age During Level And Incline Walking
(East Carolina University, 2017-05-11)
Old compared to young adults exhibit a distal-to-proximal redistribution of joint contributions to support phase mechanics during level and incline walking. Although this biomechanical plasticity is now well established ...
Factors Contributing to Clinical Judgment Development in Nursing Students During Simulation Using the Creighton Competency Evaluation Instrument
(East Carolina University, 2017-07-19)
It is imperative that nurse educators find inventive ways to advance nursing practice by developing a dynamic and divergent nursing workforce. Health care environments can be unpredictable and unsettling due to high acuity ...
Reconstructing the Culture-History of Squires Ridge (31ED365): A Multicomponent Site within the Northern Coastal Plain of North Carolina
(East Carolina University, 2017-05-31)
Until recently, the prehistoric culture-history of the Coastal Plain has remained the least understood region in North Carolina due to a lack of known sites with stratified context and dateable components. Sites, such as ...
EVALUATING A PERFORMANCE-BASED LOTTERY CONTINGENCY IN A RESIDENTIAL EDUCATIONAL SETTING TO INCREASE STAFF/RESIDENT INTERACTION
(East Carolina University, 2017-07-19)
Direct care staff are the largest working population in Residential Treatment Centers (RTCs) and spend the greatest amount of time working with residents. Unfortunately, direct care staff performance is often underwhelming, ...
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
(East Carolina University, 2017-06-22)
Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system (CNS). In this study, we characterized and examined the early metabolic changes of the triple transgenic Alzheimer's disease ...
Structural and functional analysis of the Vaccinia virus O1 virulence protein
(East Carolina University, 2017-07-26)
Poxviruses are double-stranded DNA viruses capable of causing disfiguring and deadly disease in a wide range of hosts, from insects to mammals. Orthopoxviruses (OPXV) encode many proteins that are not essential for viral ...
A Paleodemographic Study of Mortality in 1st century BC/AD Petra, Jordan
(East Carolina University, 2017-07-19)
The 1st century BC to 1st century AD population of Petra appears to have rarely suffered from infectious diseases based on the low frequency of pathological bone lesions in skeletons recovered from tombs on the site's North ...