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The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
(East Carolina University, 2011)
Diabetic patients are more susceptible to ischemia/reperfusion injury and cardiac dysfunction likely due alterations in mitochondrial calcium handling. The purpose of this work was to determine if redox-dependent changes ...
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
(East Carolina University, 2011)
Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ...
Does Minimally Invasive Robotic Surgical Treatment Alter Exercise Tolerance in Patients with Atrial Fibrillation and Mitral Regurgitation at Seven to Eleven Weeks Post-Operative?
(East Carolina University, 2009)
In the current study, we examined if exercise tolerance was going to be reduced in atrial fibrillation and mitral valve regurgitation patients post a minimally invasive surgery seven to eleven weeks when compared to ...
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
(East Carolina University, 2011)
Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ...
Skeletal Muscle Forkhead Box 3A (FOXO3A) Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2010)
In addition to suppressing protein synthesis, 5'-AMP-activated protein kinase (AMPK) stimulates muscle protein degradation through forkhead box transcription factor 3A (FOXO3A), known to promote transcription of mRNAs ...
Effects of Dietary Leucine Supplementation on Muscle Mass and Markers of Protein Degradation in Overloaded Skeletal Muscles of Young Adult and Aged Rats
(East Carolina University, 2011)
The hypertrophic response to overload in fast-twitch skeletal muscle is impaired in aged humans and rats, and upregulation of protein degradation pathways are hypothesized to be a contributing factor. Muscle growth occurs ...
EFFECTS OF A 16 WEEK PHYSICAL ACTIVITY INTERVENTION ON SERUM C-REACTIVE PROTEIN CONCENTRATIONS IN 8-11 YEAR OLD AFRICAN AMERICAN AND CAUCASIAN CHILDREN.
(East Carolina University, 2013)
C-reactive protein (CRP) is a non-specific marker of systemic inflammation that has been associated with heart disease, obesity, and metabolic disorders in adults and children. Previous physical activity interventions have ...
Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle
(East Carolina University, 2010)
Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ...
Metabolic Inflexibility in Skeletal Muscle With Obesity
(East Carolina University, 2009)
The skeletal muscle of obese individuals has a reduced capacity to oxidize lipids. The hypothesis to be tested in this dissertation is that the ability to regulate lipid oxidation in response to lipid exposure is impaired ...
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ...