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Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)
The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ...
The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers
(East Carolina University, 2017-03-16)
In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ...