It has been shown that skeletal muscle 5'-AMP-activated protein kinase (AMPK) phosphorylation and/or activity is more greatly elevated in response to resistance exercise or loading in aged rats, and that eukaryotic elongation ...

Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ...

Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...

Obesity is the result of excess energy storage due to an imbalance between energy storage and energy utilization. Excess energy is stored as triacylglycerol (TAG) in adipose tissue in various regions throughout the body. ...

The aim of the present study was to compare fat metabolism during submaximal exercise in children with a morbidly obese parent - (COP) (BMI [greater than or equal to] 40 kg/m²) to children with relatively lean parents - ...

Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...

Predators are known to cause prey to alter their morphology, life history or behavior in ways that reduce the likelihood of the prey being consumed by the predator. Seldom considered, however, are the consequences of ...

Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ...

It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ...

Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ...