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Hydrogeomorphology and Horizontal Movement of Juncus roemerianus
(East Carolina University, 2015)
Juncus roemerianus, black needlerush, is common in high marshes and occasionally in low marshes along the Mid-Atlantic and southern USA. Previous work found that J. roemerianus patches remained relatively stable in the ...
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
(East Carolina University, 2015)
Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ...
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)
Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ...
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)
In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ...
Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
(East Carolina University, 2015)
Bacterial infections are a significant health problem that can be detrimental to the human population. It is estimated that bacterial infections are responsible for billions of dollars’ worth of damages in the health care ...
Fishing For The Evolutionary Bases Of Female Ornamentation
(East Carolina University, 2015)
Sexual dimorphism, or phenotypic differentiation of the sexes, is widespread amongst animals. It is understood mainly in the context of sexual selection, i.e. selection on mating success, with such selection typically ...
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)
Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ...
Evaluating Land Use Effects On The Stinging Sea Nettle : Chrysaora Quinquecirrha: Are Shoreline Hardening Structures Creating New Habitat For A Nuisance Species?
(East Carolina University, 2015)
There is considerable debate as to whether global jellyfish populations are experiencing an overall population growth due to human activities or have been pulsing in a long-term natural rhythm. Empirical data to support ...
Population Structure Of River Herring In Albemarle Sound, North Carolina, Inferred From Geometric Morphometrics And Otolith Shape Analysis
(East Carolina University, 2015)
Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis, collectively known as River herring, use tributaries of the Albemarle Sound, North Carolina as spawning and nursery habitats. Stocks of these anadromous ...
Assessing The Monophyly Of Red Algae And Green Plants Via Core Conserved Informational Genes
(East Carolina University, 2015)
For well over a century the existence of a monophyletic relationship between red algae and green plants has been debated. Many scholars have sought to address this issue, however, a consistent solution to the problem has ...