A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains
Jones, Sherri M.; Johnson, Kenneth R.; Yu, Heping; Erway, Lawrence C.; Alagramam, Kumar N.; Pollak, Natasha; Jones, Timothy A.
The purpose of this research was to identify vestibular deficits in mice using linear vestibular evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 strains with known genetic mutations and 6 inbred background strains were analyzed and descriptive statistics generated for each strain. Response parameters from mutant homozygotes were compared with heterozygote and/or background controls and all strain averages were contrasted to normative ranges. Homozygotes of the following recessivemutations had absent VsEPs at the ages tested: Espnje, Atp2b2dfw-2J, Spnb4qv-lnd2J, Spnb4qv-3J, Myo7ash1, Tmiesr, Myo6sv, jc, Pcdh15av-J, Pcdh15av-2J, Pcdh15av-3J, Cdh23v-2J, Sans js, hr, Kcne1pkr, and Pou3f4del. These results suggest profound gravity receptor deficits for these homozygotes, which is consistent with the structural deficits that have been documented for many of these strains. Homozygotes of Catna2cdf, Grid2ho4J, Wnt1sw, qk, and Mbpshi strains and heterozygotes of Grid2lc had measurable VsEPs but one or more response parameters differed from the respective control group (heterozygote or background strain) or were outside normal ranges. For example, qk and Mbpshi homozygotes showed significantly prolonged latencies consistent with the abnormal myelin that has been described for these strains. Prolonged latencies may suggest deficits in neural conduction; elevated thresholds suggest reduced sensitivity, and reduced amplitudes may be suggestive for reduced neural synchrony. One mutation, Otx1jv, had all VsEP response parameters within normal limits—an expected finding because the abnormality in Otx1jv is presumably restricted to the lateral semicircular canal. Interestingly, some heterozygote groups also showed abnormalities in one or more VsEP response parameters, suggesting that vestibular dysfunction, although less severe, may be present in some heterozygous animals. Originally published in Journal of the Association for Research in Otolaryngology Vol. 6 No. 4 2005.
Jones, Sherri M., & Johnson, Kenneth R., & Yu, Heping, & Erway, Lawrence C., & Alagramam, Kumar N., & Pollak, Natasha, & Jones, Timothy A.. (December 2005). A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains. , (. Retrieved from http://hdl.handle.net/10342/3021
Jones, Sherri M., and Johnson, Kenneth R., and Yu, Heping, and Erway, Lawrence C., and Alagramam, Kumar N., and Pollak, Natasha, and Jones, Timothy A.. "A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains". . . (.), December 2005. January 18, 2020. http://hdl.handle.net/10342/3021.
Jones, Sherri M. and Johnson, Kenneth R. and Yu, Heping and Erway, Lawrence C. and Alagramam, Kumar N. and Pollak, Natasha and Jones, Timothy A., "A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains," , no. (December 2005), http://hdl.handle.net/10342/3021 (accessed January 18, 2020).
Jones, Sherri M., Johnson, Kenneth R., Yu, Heping, Erway, Lawrence C., Alagramam, Kumar N., Pollak, Natasha, Jones, Timothy A.. A Quantitative Survey of Gravity Receptor Function in Mutant Mouse Strains. . December 2005; () . http://hdl.handle.net/10342/3021. Accessed January 18, 2020.
East Carolina University