Browsing Kinesiology by Author "Brault, Jeffrey J."
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AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
Davis, Patrick R. (East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
Verhoeven, Nicolas (East Carolina University, 2018-07-17)Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ... -
AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
Miller, Spencer (East Carolina University, 2017-06-02)Skeletal muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and ... -
Constitutively Active CaMKKα Stimulates Skeletal Muscle Glucose Uptake in Insulin-Resistant Mice In Vivo
Hinkley, J. Matthew; Ferey, Jeremie L.; Brault, Jeffrey J.; Smith, Cheryl A. S.; Gilliam, Laura A. A.; Witczak, Carol A. (2014-01) -
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
Bollinger, Lance M. (East Carolina University, 2013)Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ... -
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
Roseno, Steven L. (East Carolina University, 2013)Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ... -
Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle
McMillin, Shawna L.; Stanley, Erin C.; Weyrauch, Luke A.; Brault, Jeffrey J.; Kahn, Barbara B.; Witczak, Carol A. (2021-05-06) -
Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy
Hakimi, Javid (East Carolina University, 1/13/16)Skeletal muscle atrophy caused by denervation is a serious consequence of neuropathic disease, especially diabetes. However, the only proven treatment for muscle atrophy is exercise, which can be difficult or impossible ... -
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
Roseno, Steven L.; Davis, Patrick R.; Bollinger, Lance M.; Powell, Jonathan J. S.; Witczak, Carol A.; Brault, Jeffrey J. (2015-11-04)Background: A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ... -
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
Roseno, Steven L.; Davis, Patrick R.; Bollinger, Lance M.; Powell, Jonathan J. S.; Witczak, Carol A.; Brault, Jeffrey J. (2015-11)