Browsing Kinesiology by Author "Cortright, Ronald N."
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The Association Between Lactate and Muscle Aerobic Substrate Oxidation: Is Lactate an Early Marker for Metabolic Disease in Healthy Subjects?
Broskey, Nicholas T.; Tanner, Charles J.; Zheng, Donghai; Cortright, Ronald N.; Yang, Zhen W.; Khang, Nkaujyi; Houmard, Joseph A.; Pories, Walter J.; Jones, Terry E.; Yang, Josh; Dohm, G. Lynis (2021) -
Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle
Kane, Daniel A. (East Carolina University, 2010)Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ... -
Mitochondrial Oxidative Capacity In Human Skeletal Muscle: Association with Plasma Lactate Concentration
Cook, Jessica (East Carolina University, 2018-07-11)ABSTRACT Background: Metabolic disease is a growing concern for public health. Obesity and Type II Diabetes are an epidemic and a phenotype for insulin resistance in human skeletal muscle. A reduced mitochondrial function ... -
Peroxisomal-Mitochondrial Metabolic Interactions in Lipid Metabolism in Human Skeletal Muscle
Huang, Tai-Yu (East Carolina University, 2016-11-16)Peroxisomal activity and associated functions, including [beta]-oxidation contributions toward maintaining cellular lipid homeostasis, is poorly defined in extra hepatic tissues, most especially in human skeletal muscle ... -
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
Ellis, Rocío Jazmin (East Carolina University, 2011)Obesity is considered a major health threat to the U.S. due to being a strong risk factor for developing type 2 diabetes and other metabolic diseases. The prevalence and severity of obesity is even greater among some ... -
SKELETAL MUSCLE LIPID PARTITIONING : CONSEQUENCES OF ALTERATIONS IN ACYL-COA SYNTHETASE-5 AND DIGLYCERIDE ACYLTRANFERASE-1 EXPRESSION
Woodlief, Tracey L. (East Carolina University, 2011)An oversupply of fatty acids and inadequacies in their partitioning toward oxidation and/or storage will lead to disruptions in cellular homeostasis. Reductions in mitochondrial content and lower rates of fatty acid ... -
THE RELATIONSHIP BETWEEN LACTATE, MITOCHONDRIA, AND PEROXISOMES IN HUMAN SKELETAL MUSCLE
Dunbar, Keith Winston (East Carolina University, 2018-05-03)Human metabolism is a complex mechanism involving many interdependent parts. The purpose of this paper is to explore the relationship or lack thereof between lactate, mitochondria, and peroxisomes in human skeletal muscle. ...