Browsing Kinesiology by Author "Gavin, Timothy Patrick"
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AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
Zwetsloot, Kevin A.; Westerkamp, Lenna M.; Holmes, Burton F.; Gavin, Timothy Patrick (East Carolina UniversityEast Carolina University, 2008-12-15)5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ... -
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
Wooldridge, Anne A.; Fortner, Christopher N.; Lontay, Beata; Akimoto, Takayuki; Neppl, Ronald L.; Facemire, Carie; Datto, Michael B.; Kwon, Ashley; McCook, Everett; Li, Ping; Wang, Shiliang; Thresher, Randy J.; Miller, Sara E.; Perriard, Jean-Claude; Gavin, Timothy Patrick; Hickner, Robert C.; Coffman, Thomas M.; Somlyo, Avril V.; Yan, Zhen; Haystead, Timothy A. J. (East Carolina University, 2008-04-25)In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ... -
Does Minimally Invasive Robotic Surgical Treatment Alter Exercise Tolerance in Patients with Atrial Fibrillation and Mitral Regurgitation at Seven to Eleven Weeks Post-Operative?
Patel, Leena Jayesh (East Carolina University, 2009)In the current study, we examined if exercise tolerance was going to be reduced in atrial fibrillation and mitral valve regurgitation patients post a minimally invasive surgery seven to eleven weeks when compared to ... -
Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats
Sloan, Ruben Carnell (East Carolina University, 2009)Gastric bypass surgery (RYGBP) for the treatment of obesity has proven to clinically reverse type 2 diabetes mellitus. RYGBP involves both gastric reduction and bypass of the proximal small intestine. Duodenal-Jejunal ... -
Gender Differences in Aerobic and Work Capacity During Plantar Flexion Exercise
Stagner, Lindsay (East Carolina University, 2009)Maximal oxygen consumption (VO2max) is lower in females compared to males during traditional whole body, systemic exercise. These differences in VO2max between men and women are still present even after correcting for ... -
No difference in the skeletal muscle angiogenic response
Gavin, Timothy Patrick; Ruster, Rebecca S.; Carrithers, John A.; Zwetsloot, Kevin A.; Kraus, Raymond M.; Evans, Christopher A.; Knapp, Deborah J.; Drew, James L.; McCartney, Jennifer S.; Garry, Joseph P.; Hickner, Robert C. (East Carolina University, 2007-11)Ischaemia-induced skeletalmuscle angiogenesis is impaired in aged compared with young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared ... -
Potential Mechanisms for Amelioration of Type 2 Diabetes Following Bariatric Surgery
Reed, Melissa Anne (East Carolina University, 2011)Severe obesity and Type 2 Diabetes (T2DM) are worldwide health concerns reaching epidemic proportions. Roux-en-Y gastric bypass (RYGB) has been shown to elicit a rapid and durable improvement and/or remission of T2DM in ... -
SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS
Ernst, Jacob Matthew (East Carolina University, 2012)Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower ... -
VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING
Kehe, Sarah (East Carolina University, 2012)Mean arterial pressure (MAP) is regulated through changes in cardiac output (Q) and total peripheral resistance (TPR), where Q = heart rate (HR) x stroke volume (SV). Healthy heart rhythms have inherent variability and a ...