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Now showing items 11-19 of 19
Intramuscular Lipid Metabolism, Insulin Action and Obesity
(East Carolina University, 2009-01)
With the increasing prevalence of obesity, research has focused on the molecular mechanism(s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations within muscle, such as changes in the cellular ...
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)
Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ...
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
(East Carolina University, 2014)
Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ...
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
(2015-11-04)
Background:
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ...
Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)
Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ...
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)
Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...
The effects of statins on mitochondrial function
(East Carolina University, 2013)
Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition ...
THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ...
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
(East Carolina University, 2013)
Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ...