Author | Busija, David W. | en_US |
Author | Bari, Ferenc | en_US |
Author | Domoki, Ferenc | en_US |
Author | Louis, Thomas | en_US |
Date Accessioned | 2011-02-17T15:36:55Z | en_US |
Date Accessioned | 2011-05-17T13:03:53Z | |
Date Available | 2011-02-17T15:36:55Z | en_US |
Date Available | 2011-05-17T13:03:53Z | |
Date of Issue | 2007-11 | en_US |
Identifier (Citation) | Brain Research Reviews; 56:1 p. 89-100 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3234 | en_US |
Description | Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation. Originally published Brain Research Review, Vol. 56, No. 1, Nov 2007 | en_US |
Language | en_US | en_US |
Publisher | East Carolina University | en_US |
Related URI | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYS-4NYD8JS-2&_user=634873&_coverDate=11%2F30%2F2007&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=67553593a0cbb1b94c99e8565b897e83&searchtype=a | en_US |
Rights | Author notified of opt-out rights by Cammie Jennings prior to upload of this article. | en_US |
Subject | Glutamate | en_US |
Subject | Cerebral circulation | en_US |
Subject | Cerebral arteries | en_US |
Subject | Nitric Oxide | en_US |
Subject | Neurons | en_US |
Subject | Ischemia | en_US |
Subject | N-methyl-D-aspartate receptors | en_US |
Subject | Rats | en_US |
Subject | Rabbits | en_US |
Subject | Piglets | en_US |
Title | Mechanisms Involved in the Cerebrovascular Dilator Effects of N-methyl-D-aspartate in Cerebral Cortex | en_US |
Type | Article | en_US |
Identifier (PMID) | PMC2174154 | en_US |
Identifier (DOI) | 10.1016/j.brainresrev.2007.05.011 | |