Author | El-Mas, Mahmoud M. | en_US |
Author | Abdel-Rahman, Abdel A. | en_US |
Date Accessioned | 2011-02-28T19:56:11Z | en_US |
Date Accessioned | 2011-05-17T13:10:56Z | |
Date Available | 2011-02-28T19:56:11Z | en_US |
Date Available | 2011-05-17T13:10:56Z | |
Date of Issue | 2009-01-16 | en_US |
Identifier (Citation) | Life Sciences; 84:3-4 p. 111-118 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3260 | en_US |
Description | Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses
elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in
telemetered female rats.
Main methods—The effects of α-methyldopa or rilmenidine on blood pressure (BP), heart rate
(HR) and their variability were investigated in rats that received liquid diet without or with ethanol
(5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP
and HR variability) in the absence or presence of ethanol, three time-domain indices of hemodynamic
variability were measured: (i) standard deviation of mean arterial pressure (SDMAP), (ii) standard
deviation of beat-to-beat intervals, and (iii) root mean square of successive differences in R-R
intervals.
Key findings—In liquid diet-fed control rats, i.p. rilmenidine (600 μg/kg) or α-methyldopa (100
mg/kg) reduced BP along with decreases and increases, respectively, in HR. Both drugs had no effect
on HR variability but reduced BP variability (SDMAP), suggesting a reduced vasomotor sympathetic
tone. Ethanol feeding attenuated reductions in BP and SDMAP evoked by α-methyldopa but not by
rilmenidine.
Significance—We conclude that chronic ethanol preferentially compromises α2- but not I1-
receptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic
activity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive
alcoholic females. | en_US |
Language | en_US | en_US |
Publisher | East Carolina University | en_US |
Related URI | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-4TY49X7-1&_user=634873&_coverDate=01%2F16%2F2009&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033758&_version=1&_urlVersion=0&_userid=634873&md5=e5eafa969f754c9ae4c304e07cf62421&searchtype=a | en_US |
Rights | Author notified of opt-out rights by Cammie Jennings. | en_US |
Subject | Ethanol | en_US |
Subject | Rilmenidine | en_US |
Subject | Alpha-methyldopa | en_US |
Subject | Hypotension | en_US |
Subject | Females | en_US |
Subject | Rats | en_US |
Title | Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats | en_US |
Type | Article | en_US |
Identifier (PMID) | PMC2631659 | en_US |
Identifier (DOI) | 10.1016/j.lfs.2008.11.006 | |
Journal Name | Life Sciences | |
Journal Volume | 84 | |
Journal Issue | 3-4 | |
Article Pages | 111-118 | |