Advisor | Gavin, Timothy Patrick | en_US |
Author | Ernst, Jacob Matthew | en_US |
Date Accessioned | 2012-09-04T18:08:47Z | |
Date Available | 2014-10-01T14:45:53Z | |
Date of Issue | 2012 | en_US |
Identifier (URI) | http://hdl.handle.net/10342/3950 | |
Description | Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower pre-RYGB insulin sensitivity. Insulin sensitivity is reduced in T2DM. Skeletal muscle accounts for 60-80% of insulin mediated glucose disposal. PURPOSE: It was hypothesized that insulin sensitivity would be lowest in T2DM patients with long-duration (LD; [greater than or equal to] 8 y) compared to short-duration (SD; < 8 y). METHODS: Insulin sensitivity (Si) and the acute response to glucose (AIRg) were measured following an insulin modified intravenous glucose tolerance test (IVGTT) using Minimal Model analysis in T2DM patients (N = 14). RESULTS: There was a significant (p = 0.010) difference in Si between short and long T2DM duration (LD: 0.47 ± 0.7; SD: 1.94 ± 0.96 min/mU/ml) and a significant correlation between Si and duration of T2DM (r = -0.70; p = 0.010). There was a significant difference in AIRg between groups. There was a significant correlation between HbA1c (an index of glycemic control) and Si (r = -0.76; p = 0.002), but not between HbA1c and AIRg (r = -0.36; p = 0.204). CONCLUSIONS: Insulin sensitivity is lower in T2DM patients with longer duration of T2DM. Clinically, poor glycemic control in long duration T2DM may be partially explained by reduced skeletal muscle insulin sensitivity. | en_US |
Extent | 60 p. | en_US |
Format Medium | dissertations, academic | en_US |
Language | | en_US |
Publisher | East Carolina University | en_US |
Subject | Kinesiology | en_US |
Subject | Physiology | en_US |
Subject | Diabetes | en_US |
Subject | Duration | en_US |
Subject | Sensitivity | en_US |
Subject | Biology, Physiology | |
Library of Congress Subject Headings | Diabetes--Research | |
Library of Congress Subject Headings | Insulin | |
Library of Congress Subject Headings | Musculoskeletal system | |
Library of Congress Subject Headings | Gastric bypass | |
Title | SKELETAL MUSCLE INSULIN SENSITIVITY AND DURATION OF TYPE 2 DIABETES MELLITUS | en_US |
Type | Master's Thesis | en_US |
Department | Exercise and Sports Science | en_US |
Degree | M.S. | en_US |