Author | Liao, Duanping | |
Author | Shaffer, Michele L. | |
Author | He, Fan | |
Author | Rodriguez-Colon, Sol | |
Author | Wu, Rongling | |
Author | Whitsel, Eric A. | |
Author | Bixler, Edward O. | |
Author | Cascio, Wayne E. | |
Date Accessioned | 2016-05-31T17:06:04Z | |
Date Available | 2016-05-31T17:06:04Z | |
Date of Issue | 2011-04 | |
Identifier (Citation) | Journal of Toxicology and Environmental Health. Part a; 74:11 p. 693-705 | en_US |
ISSN | 1528-7394 | |
Identifier (URI) | http://hdl.handle.net/10342/5426 | |
Description | The acute effects and the time course of fine particulate pollution (PM2.5) on atrial fibrillation/flutter (AF) predictors, including P-wave duration, PR interval duration, and P-wave complexity, were investigated in a community-dwelling sample of 106 nonsmokers. Individual-level 24-h beat-to-beat electrocardiogram (ECG) data were visually examined. After identifying and removing artifacts and arrhythmic beats, the 30-min averages of the AF predictors were calculated. A personal PM2.5 monitor was used to measure individual-level, real-time PM2.5 exposures during the same 24-h period, and corresponding 30-min average PM2.5 concentration were calculated. Under a linear mixed-effects modeling framework, distributed lag models were used to estimate regression coefficients (βs) associating PM2.5 with AF predictors. Most of the adverse effects on AF predictors occurred within 1.5–2 h after PM2.5 exposure. The multivariable adjusted βs per 10-µg/m3 rise in PM2.5 at lag 1 and lag 2 were significantly associated with P-wave complexity. PM2.5 exposure was also significantly associated with prolonged PR duration at lag 3 and lag 4. Higher PM2.5 was found to be associated with increases in P-wave complexity and PR duration. Maximal effects were observed within 2 h. These findings suggest that PM2.5 adversely affects AF predictors; thus, PM2.5 may be indicative of greater susceptibility to AF. | en_US |
Related URI | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082849/ | en_US |
Title | Fine Particulate air Pollution is Associated with Higher Vulnerability to Atrial Fibrillation—The APACR Study | en_US |
Type | Article | en_US |
Identifier (PMID) | pmc3082849 | en_US |
Identifier (DOI) | 10.1080/15287394.2011.556056 | |
Journal Name | Journal of Toxicology and Environmental Health. Part a | en_US |
Journal Volume | 74 | en_US |
Journal Issue | 11 | en_US |
Article Pages | 693-705 | en_US |