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Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution
(East Carolina University, 2004-01)
The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish possess duplicated Hox ...
The AraC-Like Transcriptional Regulator DhbR Is Required for Maximum Expression of the 2,3-Dihydroxybenzoic Acid Biosynthesis Genes in Brucella abortus 2308 in Response to Iron Deprivation
(East Carolina University, 2008-03)
Phenotypic evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved ...
Comparison of the exoS Gene and Protein Expression in Soil and Clinical Isolates of Pseudomonas aeruginosa
(East Carolina University, 2001-04)
Exoenzyme S (ExoS) is translocated into eukaryotic cells by the type III secretory process and has been hypothesized to function in conjunction with other virulence factors in the pathogenesis of Pseudomonas aeruginosa. ...
Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs
(East Carolina University, 2004-09-20)
Background: Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription. Among the ...
Cadherins in maternal-foetal interactions: red queen with a green beard?
(East Carolina University, 2005-03-22)
Cadherins are homophilic cell surface adhesion proteins, some of which mediate interactions between maternal and foetal tissues during mammalian pregnancy. David Haig suggested that these proteins may
exhibit ‘green-beard ...
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
(East Carolina University, 2003-03-04)
The structures of membrane receptors mediating rapid, nongenomic
actions of steroids have not been identified. We describe the cloning
of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following ...
Did an ancient chlamydial endosymbiosis facilitate the establishment of primary plastids?
(East Carolina University, 2007-06)
Background: Ancient endosymbioses are responsible for the origins of mitochondria and plastids, and they contribute to the divergence of several major eukaryotic groups. Although chlamydiae, a group of obligate intracellular ...
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
(East Carolina University, 2003-03-04)
Recently we discovered a previously uncharacterized gene with the characteristics of a membrane progestin receptor (mPR) in a fish model, spotted seatrout. Here, we report the identification, cloning, and characteristics ...
Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells
(East Carolina University, 2004)
Clustered DNA damages—two or more lesions on opposing strands and within one or two helical turns—are formed in cells by ionizing radiation or radiomimetic antitumordrugs. They are hypothesized to be difficult to repair, ...
Evolution of the RNA polymerase II C-terminal domain
(East Carolina University, 2002-04-30)
In recent years a great deal of biochemical and genetic research has focused on the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II. This strongly conserved domain of tandemly ...