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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
(East Carolina University, 2010)
Breast cancer is one of the leading causes of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using ...
Coevolutionary analysis of Appalachian Xystodesmid millipedes and their symbiotic Mesostigmatid mites
(East Carolina University, 2010)
Mites (Acari) form symbiotic relationships with many animal taxa including fish, amphibians, reptiles, birds, mammals, mollusks, and arthropods. They are frequently found living on millipedes, and it has often been ...
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)
Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ...
EFFECTS OF A REVERSE OSMOSIS-WATER TREATMENT PLANT BRINY CONCENTRATE DISCHARGED INTO AN ESTUARY.
(East Carolina University, 2010)
Reverse Osmosis Water Treatment Plants (RO-WTPs) create potable water and a briny concentrate that must be disposed; often it is discharged into nearby surface waters. Currently, there is no published research to examine ...
Does history matter? : An experimental assessment of whether dragonfly colonization history affects insect biodiversity within ephemeral ponds
(East Carolina University, 2010)
Current interactions among species could have an important role in controlling biodiversity. Some studies, however, have shown that the particular time a species arrives at a site during the process of community assembly ...
Phylogenetics and Systematics of the Millipede genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae)
(East Carolina University, 2010)
The genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae) belongs to an ancient millipede lineage that has persisted since the Miocene. The group displays a Holarctic distribution with species in the eastern Nearctic, ...
Impact of Hurricane Katrina (2005) on deltaic evolution and shelf organic carbon cycling
(2010)
Sediment cores from the continental shelf adjacent to the Mississippi River delta immediately after the passage of Hurricane Katrina were used to examine the magnitude, and implications for the carbon budget, of sediment ...
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2010)
microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ...
Intron position in RNA polymerase genes and their relationship to eukaryotic phylogenies
(East Carolina University, 2010)
Over the past two decades, there has been an increasing amount of research devoted to the study of intron evolution and its relationship to eukaryotic phylogeny. Previous studies have shown that a large percentage of ...
Psf2, a member of the heterotetrameric GINS Complex, plays a role in cell cycle progression and maintenance of genomic integrity
(East Carolina University, 2010)
Multiple proteins are involved in the complete and accurate replication of the genome during S phase of the cell cycle. At the G1/S phase transition, the heterotetrameric GINS complex is recruited to the origin, and ...