Search
Now showing items 21-30 of 146
ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM
(East Carolina University, 2012)
Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS, a hetero-tetrameric protein complex is known to be essential for the initiation and progression of ...
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)
Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ...
DOES THE QUANTITY OF RESOURCES IN THE ENVIRONMENT ALTER THE IMPACT OF MULTIPLE PREDATORS ON THEIR PREY?
(East Carolina University, 2013)
Predation is an important biological process affecting prey populations and most prey in nature are exposed to multiple predator species. Much research has revealed that the combined effect of multiple predators on their ...
CAN NUTRIENT ADDITIONS MEDIATE GAPE LIMITED PREDATION IN LARVAL RANA SPHENOCEPHALA?
(East Carolina University, 2013)
Some predators are limited in the size prey item that they can catch and consume, and this is referred to as "gape limited". Prey found with these predators may have the ability to respond by growing rapidly to reach a ...
Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
(East Carolina University, 2012)
Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ...
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
(East Carolina University, 2012)
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ...
IDENTIFICATION OF GEOCHEMICAL TRACERS WITHIN BIOMINERALS OF JUVENILE AND LARVAL MERCENARIA MERCENARIA : IMPLICATIONS FOR MODELING LARVAL DISPERSAL
(East Carolina University, 2013)
This study was designed to investigate the application of geochemical signals within biominerals to identify site fidelity and natal origin of the commercially valuable bivalve Mercenaria mercenaria. My first study ...
The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation
(East Carolina University, 2013)
Gastrin is a gastrointestinal peptide hormone synthesized in G cells and secreted in the antrum of the stomach. Though its primary role is to stimulate the secretion of gastric acid by parietal cells, it is also involved ...
EFFECTS OF A REVERSE OSMOSIS-WATER TREATMENT PLANT BRINY CONCENTRATE DISCHARGED INTO AN ESTUARY.
(East Carolina University, 2010)
Reverse Osmosis Water Treatment Plants (RO-WTPs) create potable water and a briny concentrate that must be disposed; often it is discharged into nearby surface waters. Currently, there is no published research to examine ...
Government and Medicine: the evolution of the Chinese health care system
(2011-04-29)
China’s diverse political history offers the unique opportunity to explore how a nation’s government impacts its approach to medicine and public health. The author found a correlation between Chinese government and health. ...