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Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
(East Carolina University, 2012)
Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ...
Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
(East Carolina University, 2012)
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. ...
IDENTIFICATION OF GEOCHEMICAL TRACERS WITHIN BIOMINERALS OF JUVENILE AND LARVAL MERCENARIA MERCENARIA : IMPLICATIONS FOR MODELING LARVAL DISPERSAL
(East Carolina University, 2013)
This study was designed to investigate the application of geochemical signals within biominerals to identify site fidelity and natal origin of the commercially valuable bivalve Mercenaria mercenaria. My first study ...
The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation
(East Carolina University, 2013)
Gastrin is a gastrointestinal peptide hormone synthesized in G cells and secreted in the antrum of the stomach. Though its primary role is to stimulate the secretion of gastric acid by parietal cells, it is also involved ...
EFFECTS OF A REVERSE OSMOSIS-WATER TREATMENT PLANT BRINY CONCENTRATE DISCHARGED INTO AN ESTUARY.
(East Carolina University, 2010)
Reverse Osmosis Water Treatment Plants (RO-WTPs) create potable water and a briny concentrate that must be disposed; often it is discharged into nearby surface waters. Currently, there is no published research to examine ...
Government and Medicine: the evolution of the Chinese health care system
(2011-04-29)
China’s diverse political history offers the unique opportunity to explore how a nation’s government impacts its approach to medicine and public health. The author found a correlation between Chinese government and health. ...
Does history matter? : An experimental assessment of whether dragonfly colonization history affects insect biodiversity within ephemeral ponds
(East Carolina University, 2010)
Current interactions among species could have an important role in controlling biodiversity. Some studies, however, have shown that the particular time a species arrives at a site during the process of community assembly ...
Phylogenetics and Systematics of the Millipede genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae)
(East Carolina University, 2010)
The genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae) belongs to an ancient millipede lineage that has persisted since the Miocene. The group displays a Holarctic distribution with species in the eastern Nearctic, ...
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2010)
microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ...
Historical Ecology of Striped Bass Stocking in the Southeastern United States
(East Carolina University, 2012)
Striped bass (Morone saxatilis) is the most recreationally and commercially important non-salmonid fish species in the continental United States. As such, it has been exploited to the point of collapse at various points ...