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The Fur-like regulator Mur controls the expression of the gene encoding the manganese transporter MntH in Brucella abortus 2308 in response to manganese availability
(East Carolina University, 2011)
Brucella abortus is a Gram-negative, [alpha]-proteobacterium that causes bovine brucellosis, a prevalent zoonotic disease in many areas of the world. Brucella abortus is an intracellular pathogen that survives and ...
Effects of Nicotine on Caenorhabditis elegans survival, reproduction, and gene expressions : Development of an Invertebrate Animal Model for Drugs of Abuse
(East Carolina University, 2011)
Although much is known about the addictive effects of nicotine, the molecular mechanisms of nicotine-induced effects remain largely unclear. Specifically, little is known about the effects of nicotine on gene expression, ...
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
(East Carolina University, 2011)
Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ...
Transcriptional Analysis of the Bacteroides fragilis Starch Utilization Operon, osuA
(East Carolina University, 2011)
The opportunistic pathogen Bacteroides fragilis is a symbiotic organism that inhabits the human gastrointestinal tract where it utilizes dietary and host-derived polysaccharides as carbon and energy sources. If abdominal ...
DISINTEGRIN-LIKE DOMAIN IN KSHV ENCODED gB IS A NECESSITY TO PROMOTE VIRUS LATENCY
(East Carolina University, 2011)
KSHV glycoprotein B (gB) is a lytic structural protein expressed on the envelope of mature virions and on the membrane of cells supporting lytic infection. Previous studies have identified that in addition to the role of ...
Hypoxia and Serum Deprivation in Human Mesenchymal Stem Cells, and the Protective Role of Thymosin [Beta]-4
(East Carolina University, 2011)
Background: Current literature suggests nutrient deprivation and hypoxia affect human mesenchymal stem cell (hMSC) survival after cell transplantation. Wound-healing protein Thymosin [beta]-4 (T[beta]-4) has been shown ...
Effect of MicroRNA-34c on Regenerative Axon Growth in Dorsal Root Ganglion Neurons of the Peripheral Nervous System
(East Carolina University, 2011)
The peripheral nervous system is unique in its ability to regenerate axons after injury. Our lab previously assessed the miRNA expression levels of the regenerating sciatic nerve which indicated miR-34c up-regulation. ...
Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression
(2011)
Background
Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient ...
EGID: an ensemble algorithm for improved genomic island detection in genomic sequences
(2011)
Genomic islands (GIs) are genomic regions that are originally transferred from other organisms. The detection of genomic islands in genomes can lead to many applications in industrial, medical and environmental contexts. ...
Conspecific brood parasitism in the tropics: an experimental investigation of host responses in common moorhens and American purple gallinules
(2011-11)
Species occupying a broad latitudinal range may show greater phenotypic plasticity in behavior than species with smaller ranges or more specific habitat requirements. This study investigates for the first time the occurrence ...