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A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation
(2015)
The relative ease, speed and biological scope of CRISPR/Cas9-based reagents for genomic manipulations are revolutionizing virtually all areas of molecular biosciences, including functional genomics, genetics, applied ...
Population Structure Of River Herring In Albemarle Sound, North Carolina, Inferred From Geometric Morphometrics And Otolith Shape Analysis
(East Carolina University, 2015)
Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis, collectively known as River herring, use tributaries of the Albemarle Sound, North Carolina as spawning and nursery habitats. Stocks of these anadromous ...
Reproductive Plasticity In Two Subspecies Of A Cleistogamous Plant, Triodanis Perfoliata
(East Carolina University, 2015)
Dimorphic cleistogamy is an intriguing reproductive strategy in which a plant produces both closed (cleistogamous), obligately selfing flowers and open (chasmogamous) flowers. Phenotypic plasticity in the production of ...
Species And Stage Specific Developmental Toxicity Of Endosulfan Exposure In Hyla Cinerea And Ranitomeya Imitator
(East Carolina University, 2015)
During ontogeny, organisms pass through critical periods of heightened vulnerability to disruptive exogenous agents. In organisms with complex life cycles, these developmental windows result in variable susceptibility ...
Exposure To Elevated Prenatal Testosterone Metabolites Induce Autism-Like Behavior In Rats : Evidence For The Extreme Male Brain And Implications For Human Health
(East Carolina University, 2015)
Neurodevelopmental disorders such as autism spectrum disorder (ASD) originate during early brain development and are the result of complex interactions between genetic and environmental factors. Disruptions in the prenatal ...
Gene Expression Divergence Between Zebra Finch (Taeniopygia Guttata) Subspecies And Gene Regulation In Hybrids
(East Carolina University, 2015)
Since the publication of Mayr's Systematics and the Origin of Species, birds have been important model organisms for studies regarding evolutionary processes such as sexual selection and speciation. In this study, I will ...
Investigating the Role of CtBP in Colorectal Cancer
(2015-04-29)
Recent studies in breast cancer tissue have demonstrated that C-terminal binding protein (CtBP) over-expression induces stem cell-like features and genome instability; whereas CtBP depletion or caloric restriction reverses ...
Nicotine Controlof Germline Cell Fate in Caenorhabditis elegans
(2015-05)
Nicotine dependence is the single largest cause of preventable death in the world, claiming 480,000 lives each year in the US alone, including those caused by secondhand smoke. In this study, we investigated the biological ...
Fishing For The Evolutionary Bases Of Female Ornamentation
(East Carolina University, 2015)
Sexual dimorphism, or phenotypic differentiation of the sexes, is widespread amongst animals. It is understood mainly in the context of sexual selection, i.e. selection on mating success, with such selection typically ...
A Biopsychosocial Examination of Transcatheter Aortic Valve Replacement Health Outcomes
(East Carolina University, 2015)
Cardiovascular disease (CVD) is the leading cause of death in the world accounting for 17.3 million deaths annually. Transcatheter aortic valve replacement (TAVR) was developed 13 years ago to treat people suffering from ...