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    The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

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    Author
    Efird, Jimmy T.; Toland, Amanda E.; Lea, C. Suzanne; Phillips, Christopher J.
    Abstract
    The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important population at great risk for CSCC. An association has been reported between oral contraceptive (OC) use, human papillomavirus virus (HPV) and cervical cancer, and there could be a similar association for CSCC. The cutaneous HPV β-E6 protein, a close cousin of the transformative E6 protein underlying anogenital cancers, has been shown to inhibit apoptosis in response to UVR damage and stimulate morphologic transformation in rodent fibroblast cell lines. Furthermore, OC use has been shown to enhance HPV transcription and may contribute to CSCC risk through this pathway.
    URI
    http://hdl.handle.net/10342/5842
    Subject
     cutaneous squamous cell carcinoma; human papillomavirus virus; oral contraceptives 
    Date
    2011-03
    Citation:
    APA:
    Efird, Jimmy T., & Toland, Amanda E., & Lea, C. Suzanne, & Phillips, Christopher J.. (March 2011). The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma. Clinical Medicine Insights. Oncology, (55-75. Retrieved from http://hdl.handle.net/10342/5842

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Efird, Jimmy T., and Toland, Amanda E., and Lea, C. Suzanne, and Phillips, Christopher J.. "The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma". Clinical Medicine Insights. Oncology. . (55-75.), March 2011. December 14, 2019. http://hdl.handle.net/10342/5842.
    Chicago:
    Efird, Jimmy T. and Toland, Amanda E. and Lea, C. Suzanne and Phillips, Christopher J., "The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma," Clinical Medicine Insights. Oncology 5, no. (March 2011), http://hdl.handle.net/10342/5842 (accessed December 14, 2019).
    AMA:
    Efird, Jimmy T., Toland, Amanda E., Lea, C. Suzanne, Phillips, Christopher J.. The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma. Clinical Medicine Insights. Oncology. March 2011; 5() 55-75. http://hdl.handle.net/10342/5842. Accessed December 14, 2019.
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