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Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
(2017-10-10)
Cannabinoids include the active constituents of Cannabis or are molecules that mimic the structure and/or function of these Cannabis-derived molecules. Cannabinoids produce many of their cellular and organ system effects ...
Author Impact Metrics in Communication Sciences and Disorder Research
(2017-09)
Purpose: The purpose was to examine author-level impact metrics for faculty in the communication sciences and disorder research field across a variety of databases.
Method: Author-level impact metrics were collected for ...
Changes in zooplankton community, and seston and zooplankton fatty acid profiles at the freshwater/saltwater interface of the Chowan River, North Carolina
(2017-08-16)
The variability in zooplankton fatty acid composition may be an indicator of larval fish habitat quality as fatty acids are linked to fish larval growth and survival. We sampled an anadromous fish nursery, the Chowan River, ...
Bevacizumab in the treatment of NSCLC: patient selection and perspectives
(2017-12-14)
Non-small-cell lung cancer (NSCLC) represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 ...
Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
(2017-10)
Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that ...
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
(2017-08-24)
Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to
cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ...
Clinical assessment of medical students in the Emergency Department, A National Consensus Conference
(2017-01)
BACKGROUND
The clinical assessment of medical students in the emergency department (ED) is a highly variable process in which clerkship directors (CD) create and use institution-specific tools, many with unproven reliability ...
Beyond Beck's triad: A case report of cardiac tamponade in a “super-super” obese patient
(2017-06)
Cardiac tamponade is a medical emergency with various etiologies. Prompt recognition of the signs and symptoms of cardiac tamponade is critical but potentially full of challenge in clinical practice [1]. Here we report a ...
Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
(2017-12-06)
Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we ...
Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV)
(2017-01)
The specific health effects of direct inhalation of fine minerogenic dusts generated by natural soil surfaces remain poorly known and relatively little researched. To learn more about this exposure and its contri- bution ...