Browsing Honors College by Author "Ables, Elizabeth Tweedie"
-
Characterizing the role of the Early Gene at 23 (E23) in Drosophila Melanogaster Oogenesis
Kothadia, Radhika J (East Carolina University, 2016-04-29)Drosophila melanogaster (fruit fly) females undergo oogenesis to create oocytes from undifferentiated stem cells in the ovary. Similar to estrogen in humans, the steroid hormone ecdysone in fruit flies has a known role in ... -
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
Davenport, Lindsay L (East Carolina University, 2017-05-05)Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ... -
Investigating the role of TER94 in Drosophila melanogaster germ cells
Gowdy, Alyssa Celine (East Carolina University, 2021-05-28)Mutations in Valosin-Containing Protein (VCP) can lead to onset of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease; however, the intracellular functions of VCP in cells remain unclear. To study the ... -
Molecular chaperone Tetratricopeptide repeat protein 2 (Tpr2) is essential for germline stem cell self-renewal and timely cyst divisions in Drosophila melanogaster oogenesis
Phillips, Morgan L (East Carolina University, 2019-05-02)Steroid hormones influence cell proliferation and cell fate in developing and injured tissues. Although steroid hormone signaling has been well-studied, the precise mechanisms by which cells specifically receive steroid ... -
THE ROLE OF HNRNPS ON THE ESTABLISHMENT AND MAINTENANCE OF GERMLINE STEM CELLS IN DROSOPHILA MELANOGASTER
Holt, Vivian (East Carolina University, 2018-05-03)An organism’s ability to grow and regulate tissue repair relies on the stimulation of stem cells in response to changes in physiological state, such as cell damage, sexual maturation and growth. Tissue-resident stem cells ... -
The Role of Oatp74D, an Ecdysone Importer, in the Drosophila ovary.
Powell, Amanda M (East Carolina University, 2022-05-04)Oogenesis is the progression of germ cells through mitotic expansion, differentiation into an oocyte, and successful completion of meiosis. Steroid hormones play critical roles in this process in diverse organisms. In ... -
The Role of Pre-Replication Complex Proteins in Drosophila Ovarian Stem Cell Maintenance and Proliferation
Safin, Justin R (East Carolina University, 2017-05-05)Cancer stem cells (CSCs) may hold the key to advances in cancer research. Like adult tissue-specific stem cells, CSCs are able to self-renew and last a lifetime. These shared characteristics can thus be used to help learn ...