Browsing Honors College by Author "Allen, William E."
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Installation of Metal-Binding Functionality at Lysine Residues via Azide-Alkyne "Click Chemistry"
Baucom, Matthew (2015-04-29)A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared in a “click reaction” by treating Fmoc-Lys(N3)-OH with 2-ethynylpyridine and Cu(I). It was incorporated into a 12-residue ... -
Membrane Localization of Pyrene-Trehalose Conjugates (PYRETs)
Hagwood, Abigail (East Carolina University, 2018-05-01)The disaccharide trehalose is found in many organisms that can survive in extremely cold or dry environments. According to the “hydration hypothesis,” trehalose interacts with the glycerol/phosphate regions of lipid bilayers ... -
Recognition of bacterial lipid headgroups by fluorescent crown ether-naphthalimides
Marshall, Sarah Ruth (2015)The increasing incidence of antibiotic- resistant bacterial strains is a significant threat to human health. New antimicrobial mechanisms that feature reduced resistance potential are necessary to slow down the rapid ... -
STABILIZATION OF THE COLLAGEN TRIPLE HELIX WITH A RUTHENIUM(II) ANCHOR
Banzon, Patrick D. (East Carolina University, 2017-05-04)Two collagen analogues based on a (Pro-Hyp-Gly)7 core were given metal-binding ability by linking histidine to either the N- or C- termini using a six-carbon spacer. Circular dichroism studies confirmed that the isomers, ...